Las fosas nasales nos defienden del resfriado común y fijan la gravedad de la infección
Un estudio de científicos de la Universidad de Yale reveló que las fosas nasales desempeñan un papel clave en la defensa contra el resfriado común y en la determinación de la gravedad de la infección, al coordinar respuestas antivirales que limitan la propagación del rinovirus
TL;DR
- Nasal passages defend against the common cold and influence disease severity.
- Researchers created lab-grown human nasal tissue to observe rhinovirus infections at cellular and molecular levels.
- The body's response to a virus, rather than the virus itself, is critical in determining illness and severity.
- Nasal lining cells activate antiviral defenses, including interferons, to combat rhinovirus.
- Interferons block viral entry and replication, making the environment inhospitable for the virus.
- Experimental blockage of interferon response led to rapid, widespread infection and damage in the lab model.
- Other responses, like increased mucus production and inflammation, are triggered by higher viral replication.
- Interferon response and other defense mechanisms are potential targets for new rhinovirus therapies.